acivir 200mg tablet (cipla) | Acyclovir tablets uses and side effects | MHP

DESCRIPTION

Acivir 200mg belongs to the group of medicines known as antivirals, which are required to treat infections caused by viruses.

Typically,these medicines work for only one type of virus infections. Acivir 200mg tablets also knowns as Acycloguanosine, Acivir 200mg is a prescription drugs administrated orally which is used under the supervision of medical practioners. Acivir 200mg is used with combination of other medications.

Acivir 200mg tablets is a type of nucleoside analogs (group of synthetic drugs), will inhibit the symptoms of infection contains Herpes Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV(varicella-Zoster virus) and thereby causes shingles and chickenpox.

INDICATION OF ACIVIR 200MG

Acivir 200mg tablets is indicated to lowers the pain and rapid healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster. Acivir 200mg is also indicated for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from time to time(genital herpes) and hence blocks the outbreaks of genital herpes in people affected by virus.

MECHANISM OF ACTION OF ACIVIR 200MG

Acivir 200mg isexcited by phosphorylation before to that drug will preventssynthesis ofviral DNA. Acivir changes by addition of phosphate group to a viral enzyme known as thymidine kinase has more affinity. HSV-TK or VZV-TK by phosphorylation converts into acyclovir triphosphate then combined into viral DNA, thereby Acivir 200mg tablets stops further DNA synthesis.Since Acivir attack to a selective type of viral kinase, the drugs enter and works on those cells infected with HSV or VZV, hence it Acivir 200mg will demobilize the formation of herpesvirus DNA. At high concentration has low activity in Acivir 200mg tablets uninfected cells, Here by HSV-TK or VZV-TK mutation will lead resistance to acyclovir.

ADME PROPERTIES

ABSORPTION

bad water soluble, high plasma Acivir 200mg tablets concentration after 1–2 hours and bioavailability 15–30%.

DISTRIBUTION

human serum protein binding is about 9 to 33%.

METABOLISM & ELIMINATION

half-life based concede to Acivir 200mg tablets age group neonates have t1/2 is 4 hours, Acivir 200mg children’s have 2–3 hours and for adults t1/2 is 3 hours.

Acivir 200mg tablets

DOSAGE

HERPES SIMPLEX- MUCOCUTANEOUS/ IMMUNOCOMPETENT HOST
The Acivir 200mg recommended adult dose is 200mg orally every 4 hours or 5 times a day for 10 days. Prescribed 400mg orally 3 times a day is givenfor 5 to 10 days.

FOR PEDIATRIC DOSE

less than 12 years Acivir 200mg tablets patients prescribed 40 to 80mg/kg/day orally, it can be divided into 3 to 4 times a day, max 5 to 10 days Max dose is given up to 1000mg/day 12yrs or older of patients Acivir 200mg prescribed 200mg orally 5 times a day every 4 hour. 400mg orally 3 times a day Duration: 7–10 days

HERPES SIMPLEX — MUCOCUTANEOUS/ IMMUNOCOMPROMISED HOST

The recommended adult Acivir 200mg dose is 400mg orally 3 times a day Duration: up to 5 to 10 Acivir 200mg tablets days The patient having Severe disease prescribed dose is 5mg/kg IV every 8 hours

For Acivir 200mg tablets Episodic treatment: prescribed dose is 400mg orally 3 times a day upto 5 to 14 days For pediatric dose: <12 years: 10 mg/kg IV for every 8 hours upto 7 days 12 years or older: 5 mg/kg IV for every 8 hours upto7 days continues HIV infection The patients Acivir 200mg with Mild Symptomatic Gingivostomatitis:20 mg/kg orally 4 times a day for 7 to 10 days ; Acivir 200mg Maximum dose: 400 mg Moderate to Severe Gingivostomatitis:5 to 10 mg/kg IV 3 times a day

HERPES SIMPLEX ENCEPHALITIS


The usual adult dose is10mg/kg IV for every 8 hours Duration administrated for 10days and center for Acivir 200mg tablets disease control and prevention Acivir 200mg recommends 21 days

For pediatric dose: 3 months to 12 years old : IV 10 to 20 mg/kg for every 8 hours 12 years or older: 10mg/kg IV every 8 Acivir 200mg tablets hours Duration: 10days and center for disease control and Acivir 200mg prevention recommends 21 days

HERPES ZOSTER

The Acivir 200mg tablets usual adult dose is 800mg orally every 4 hours ( 5 times a day) for 7 to 10 days Patients with Immunocompromised host Acivir 200mg dose is 10 mg/kg IV every 8 hours for 7 days Acivir 200mg Treatment Duration 7 to 14-day course (oral plus IV)

For pediatric the prescribed dose is Immunocompetent Host: -Parenteral: < 1 year: 10 mg/kg IV every 8 Acivir 200mg hours for 7 to 10 days 1 year or older: 500 mg/m2 IV every 8 hours for 7 to 10 days Oral: 12 years or older: 800 mg orally 5 times a day for 5 to 7 days Acivir 200mg tablets Immunocompromised Host: 10 mg/kg IV every 8 hours for 7 to 10 days

OVERDOSAGE

Acivir 200mg tablets contains ingestion of 100 capsules ( 20g) have been resulted has agitation, coma, seizures and lethargy. If overdose occurs Acivir 200mg provide supportive measures.

DRUG INTERACTION
Acivir 200mg tablets concomitant use with probenecid will reduce tubular secretion of acyclovir and increase the blood plasma and half- life of Acivir 200mg acyclovir. Interaction of Acivir with nephrotoxic drugs may cause increase the risk in renal function Interaction with immunostimulators will enhancing effects of acyclovir.

CONTRAINDICATION

Acivir 200mg tablets is contraindicated in Acivir 200mg patients who causes hypersensitivity to acyclovir or valacyclovir.

PRECAUTION

Acivir 200mg cause allergic reaction like breathing trouble, swelling of throat or tongue, rash, hives. Inform your doctor if symptoms occur. Discuss with your consultant about planning to Acivir 200mg tablets become pregnant or pregnancy because drug can be used if possible benefits clarify possible risk to the patients. Discuss with doctor If you had kidney disease because the excretion of drug will not perform well, Acivir 200mg will decrease the kidney function.

PREGNANCY

Category B: In animal studies it has not shown harm to the fetus and In human no enough Acivir 200mg studies carried out in pregnant women to describe the harm to the fetus. Drug used only if Acivir 200mg tablets possible benefits clarify possible risk to the patients.

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