Acivir 400mg tablet | Acyclovir tablet | MHP

DESCRIPTION

Acivir 400mg belongs to the group of medicines known as antivirals, which are required to treat infections caused by viruses.

Typically,these medicines work for only one type of virus infections. Acivir 400mg tablets is also knowns as Acycloguanosine,  is a prescription drugs administrated orally which is used under the supervision of medical practioners.    combination of other medications.

Acivir 400mg is a type of nucleoside analogs (group of synthetic drugs), will inhibit the symptoms of infection contains Herpes Acivir 400mg tablets Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV(varicella-Zoster virus) and thereby causes shingles and chickenpox.

INDICATION OF ACIVIR 400mg

Acivir 400mg tablets is indicated to lowers the pain and rapid healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster. Acivir 400mg is also indicated for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from Acivir 400mg tablets time to time(genital herpes) and hence blocks the outbreaks of genital herpes in people affected by virus.

MECHANISM OF ACTION OF ACIVIR 400mg

Acivir isexcited by phosphorylation before to that drug will preventssynthesis ofviral DNA. Acivir changes by addition of phosphate group to a viral enzyme known as thymidine kinase has more affinity. HSV-TK or VZV-TK by phosphorylation converts into acyclovir triphosphate then combined into viral DNA, thereby stops further DNA synthesis.Since Acivir attack to a selective type of viral kinase, the drugs enter and Acivir 400mg tablets works on those cells infected with HSV or VZV, hence it will demobilize the formation of herpesvirus DNA. At high concentration has low activity in uninfected cells, Here by HSV-TK or VZV-TK mutation will lead resistance to acyclovir.

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Acivir 400mg

ADME PROPERTIES

ABSORPTION

bad water soluble, high plasma concentration after 1–2 hours and bioavailability 15–30%.

DISTRIBUTION

human serum protein binding is about 9 to 33%.

METABOLISM & ELIMINATION

half-life based concede to age group neonates have t1/2 is 4 hours, children’s have 2–3 hours and for adults t1/2 is 3 hours.

DOSAGE

HERPES SIMPLEX- MUCOCUTANEOUS/ IMMUNOCOMPETENT HOST

The recommended adult dose is 400mg orally every 4 hours or 5 times a day for 10 days. Prescribed 400mg orally 3 times a Acivir 400mg tablets day is givenfor 5 to 10 days.

FOR PEDIATRIC DOSE

less than Acivir 400mg 12 years patients prescribed 40 to 80mg/kg/day orally, it can be divided into 3 to 4 times a day, max 5 to 10 days Max dose is given up to 1000mg/day 12yrs or older of patients prescribed 400mg orally 5 times a day every 4 hour. 400mg orally 3 times a day Duration: 7–10 days

HERPES SIMPLEX — MUCOCUTANEOUS/ IMMUNOCOMPROMISED HOST

The recommended adult dose is 400mg orally 3 times a day Duration: up to 5 to 10 days The patient having Acivir 400mg Severe Acivir 400mg tablets disease prescribed dose is 5mg/kg IV every 8 hours

For Episodic treatment: prescribed dose is 400mg orally 3 times a day upto 5 to 14 days For pediatric dose: <12 years: 10 mg/kg IV for every 8 hours upto 7 days 12 years or older: 5 mg/kg IV for every 8 hours upto7 days continues HIV infection The patients Acivir 400mg tablets with Mild Symptomatic Gingivostomatitis:20 mg/kg orally 4 times a day for 7 to 10 days ; Acivir 400mg Maximum dose: 400 mg Moderate to Severe Gingivostomatitis:5 to 10 mg/kg IV 3 times a day

HERPES SIMPLEX ENCEPHALITIS

The usual adult dose is10mg/kg IV for every 8 hours Duration administrated for 10days and Acivir 400mg center for disease control and prevention recommends 21 days

For pediatric dose: 3 months to 12 years old : IV 10 to 20 mg/kg for every 8 hours 12 years or older: 10mg/kg IV Acivir 400mg every 8 hours Duration: 10days and center for disease Acivir 400mg tablets control and prevention recommends 21 days

HERPES ZOSTER

The usual adult dose is 800mg orally every 4 hours ( 5 times a day) for 7 to 10 days Patients with Immunocompromised host Acivir 400mg dose is 10 mg/kg IV every 8 hours for 7 days Treatment Duration 7 to 14-day course (oral plus IV)

For pediatric the prescribed dose is Immunocompetent Host: -Parenteral: < 1 year: 10 mg/kg IV every 8 hours for 7 to 10 days 1 year or older: 500 mg/m2 IV every 8 hours for 7 to 10 days Oral: 12 years or Acivir 400mg tablets older: 800 mg orally 5 times a day for 5 to 7 days Immunocompromised Host: 10 mg/kg IV every 8 hours for 7 to 10 days

OVERDOSAGE

Acivir 400mg contains ingestion of 100 capsules ( 20g) have been resulted has agitation, coma, seizures Acivir 400mg and lethargy. If overdose occurs provide supportive measures.

DRUG INTERACTION

Acivir concomitant use with probenecid will reduce tubular secretion of acyclovir Acivir 400mg tablets and increase the blood Acivir 400mg plasma and half- life of acyclovir. Interaction of Acivir with nephrotoxic drugs may cause increase the risk in renal function Interaction with immunostimulators will enhancing effects of acyclovir.

CONTRAINDICATION

Acivir is contraindicated in Acivir 400mg patients who causes hypersensitivity to acyclovir or valacyclovir.

PRECAUTION

Acivir 400mg cause allergic reaction like breathing trouble, swelling of throat or tongue, rash, hives. Inform your doctor if symptoms occur. Discuss with your consultant about Acivir 400mg planning to become pregnant or pregnancy because drug can be used if possible benefits clarify possible risk to the patients. Discuss with doctor If you had kidney disease because the excretion of drug will not perform well, Acivir 400mg tablets will decrease the kidney function.

PREGNANCY

Category B: In animal studies it has not shown harm to the fetus and In human no Acivir 400mg tablets enough studies carried out in pregnant women to describe the harm to the fetus. Drug used only if Acivir 400mg possible benefits clarify possible risk to the patients.

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