Valcivir 1000mg tablet | valcivir uses and side effects | MHP

Valcivir 1000mg


Valcivir 1000mg , includes an active composition like valacyclovir which is pharmacologically classify as nucleoside analogue of viral DNA polymerase prohibitor.

Valcivir 1000mg tablets which belongs to synthetically classified as nucleoside analogue. present as prodrug which gets changed into an active molecule known as acyclovir.

INDICATION

The major indication of valacyclovir is used in the condition like;
Herpes simplex & herpes zoster
In adults
Valcivir 1000mg is mostly indicated for the treatment of cold sores by Herpes Labialis. Valcivir 1000mg have capability to started after the advancement of clinical signs of cold sore has not been evaluated.likewise determined in the condition like starting scene of genital herpes in immune capable grown -ups. Valcivir 1000mg is also indicated in the treatment of relapsed episodes of genital herpes in immuno competent episodes. Valcivir 1000mg is exhibit for cutting edge suppressive therapy of repetitive scenes of genital herpes in immuno skillful and HIV-1 contaminated grown-ups. Valcivir 1000mg tablets is also used for the contraction of transmission of genital herpes in immuno competent adults. Valcivir 1000mg tablets is indicated in the treatment of herpes zoster in immuno competent adults.
In pediatrics
In pediatric patients, Valcivir 1000mg tablets is includes in the therapy of cold sores with the age of greater or equal to 12 years. Valcivir 1000mg is also indicated for the therapy of chicken pox in immuno competent pediatric patients with age of 2 to less than 18 years

PHARMACOLOGY

Valcivir 1000mg tablets which represented as a prodrug that will go through phosphorylation by using viral thymidine kinase enzyme for changing of acyclovir triphosphate, an active metabolite. This active molecule is included in the prevention of herpes viral DNA replication by competitive inhibition of viral DNA polymerase. Valcivir 1000mg After injected of this metabolite into the virus &causes terminate of the developing viral DNA chain. Valacyclovir contains; TheDNA synthesis blocked Destabilizing the strand Prevention of new viral growth.

PHARMACOKINETICS

ABSORPTION

Valcivir 1000mg After oral intake of Valcivir, valacyclovir is fast absorbed from the gastrointestinal tract and Valcivir 1000mg tablets bioavailability by 54.5% plus or minus 9.1%.

DISTRIBUTION
After absorption occurs, Valcivir 1000mg the human serum protein binding capacity is 13 to 18%.

METABOLISM

Valacyclovir is rapidly absorbed and approximately 99% of drug get changes into an active Valcivir 1000mg form like acyclovir & L-valine by sustaining first pass metabolism & hepatic metabolism Valcivir 1000mg tablets by enzymatic hydrolysis.

valcivir 1000mg tablets 

ELIMINATION

Valcivir 1000mg About 89% of radioactivity gets excreted via urine. The medianvalacyclovir half-life Valcivir 1000mg tablets period occurs in 2.5 to 3.3 hours.

SIDE EFFECTS

THE MAJOR ADVERSE EFFECTS OF Valcivir ARE
Valcivir 1000mg tablets Thrombotic thrombocytopenia purpura/hemolytic uremic syndrome, Acute renal failure, Central nervous Valcivir 1000mg effects

THE COMMON SIDE EFFECTS

Low RBC Increased AST Neutropenia Valcivir 1000mg tablets Respiratory tract infection Decreased platelet Valcivir 1000mg counts Nasopharyngitis Headache Dizziness Nausea Abdominal pain

POST MARKETING EFFECTS

Valcivir 1000mg tablets Visual abnormalities Liver enzyme abnormality Hepatitis Renal failure Aplastic anemia Erythema Valcivir 1000mg multiforme Alopecia Facial
edema High blood pressure Tachycardia Anaphylactic reactions CNS disorders

DRUG INTERACTIONS OF VALCIVIR
Valcivir 1000mg No drug- drug interactions occurs in the valacyclovir treatment.

CONTRAINDICATIONS OF VALCIVIR

Valcivir 1000mg is highly contraindicated in patients with hypersensitivity reactions due to patients are contraindicated to the ingredients of Valcivir.

PREGNANCY & LACTATION

The pregnancy category of valacyclovir is B It should be used with caution. Caution should be taken while administering Valcivir 1000mg to nursing woman.

MISSED DOSE

Valcivir 1000mg Missed dose condition should be avoided by maintain the regular dosing schedule. Do not skip the dose.

If missed dose condition, Valcivir 1000mg patient should be get discuss from the medical practitioner & follow the instructions. Valcivir 1000mg tablets Avoid self-medication.

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