Zovirax 400mg tablets

DESCRIPTION

Zovirax 400mg belongs to the group of medicines known as antivirals, which are required to treat infections caused by viruses.

Typically,these medicines work for only one type of virus infections. Zovirax 400mg is also knowns as Acycloguanosine,
Zovirax 400mg is a prescription drugs administrated orally which is used under the supervision of medical practioners.
Zovirax 400mg tablets used with combination of other medications.

Zovirax 400mg is a type of nucleoside analogs (group of synthetic drugs), will inhibit the symptoms of infection contains
Herpes Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV(varicella-Zoster virus) and thereby Zovirax 400mg tablets causes shingles and chickenpox.

INDICATION

Zovirax 400mg is indicated to lowers the pain and rapid healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster.

Zovirax 400mg tablets is also indicated for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from time
to time(genital herpes) and hence blocks the outbreaks of genital herpes in people affected by virus.

MECHANISM OF ACTION

Zovirax isexcited by phosphorylation before to that drug will preventssynthesis ofviral DNA. Zovirax 400mg tablets Zovirax changes by addition of phosphate group to

a viral enzyme known as thymidine kinase has more affinity. HSV-TK or VZV-TK by Zovirax 400mg tablets phosphorylation converts into acyclovir triphosphate then combined
into viral DNA, thereby stops further DNA synthesis.Since Zovirax attack to a selective type of viral kinase, the drugs enter and works Zovirax 400mg on those cells
Zovirax 400mg infected with HSV or VZV, hence it will demobilize the formation of herpesvirus DNA. At high concentration has low activity in uninfected cells,
Here by HSV-TK or VZV-TK mutation will lead resistance to acyclovir.

Zovirax 400mg

ADME PROPERTIES

ABSORPTION

bad water soluble, Zovirax 400mg tablets high plasma concentration after 1–2 hours and bioavailability 15–30%.

DISTRIBUTION

Zovirax 400mg human serum protein binding is about 9 to 33%.

METABOLISM & ELIMINATION
half-life based Zovirax 400mg tablets concede to age group neonates have t1/2 is 4 hours, children’s have 2–3 hours and for adults t1/2 is 3 hours.

OVERDOSAGE

Zovirax 400mg contains ingestion of 100 capsules ( 20g) have been resulted has agitation, coma, Zovirax 400mg tablets seizures and lethargy. If overdose occurs provide supportive measures.

DRUG INTERACTION
Zovirax 400mg concomitant use with probenecid will reduce tubular secretion of acyclovir and increase the blood plasma and half- life of acyclovir. Interaction of Zovirax with nephrotoxic Zovirax 400mg tablets drugs may cause increase the risk in renal function Interaction with immunostimulators will enhancing effects of acyclovir

CONTRAINDICATION

Zovirax is contraindicated in Zovirax 400mg tablets patients who causes hypersensitivity to acyclovir or valacyclovir.

PRECAUTION

Zovirax 400mg cause allergic reaction like breathing trouble, swelling of throat or tongue, rash, hives.
Inform your doctor if symptoms occur. Discuss with your consultant about planning to become pregnant Zovirax 400mg tablets or pregnancy because drug
can be used if possible benefits clarify possible risk to the patients. Discuss with doctor If you had kidney disease because
the excretion of drug Zovirax 400mg tablets will not perform well, Zovirax 400mg will decrease the kidney function.

PREGNANCY

Category B: In animal studies it has not shown harm to the fetus and In human no enough studies Zovirax 400mg tablets carried out in pregnant women
to Zovirax 400mg describe the harm to the fetus. Drug used only if possible benefits clarify possible risk to the patients.

MISSED DOSE

If dose missed by patients then take the dose immediately. If next dose time reaches leave the missed dose Zovirax 400mg tablets and continue the regular schedule.
Zovirax 400mg avoid taking double dose at a time. Please consult the doctor for further details.

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